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Adult T-cell leukemia/lymphoma in an adolescent presenting with skin lesions |
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| Authors: | Lucas Catherine T Gillis Kendra J Ness Jayne M Hammers Yuki A Crawford David F Kelly David R Theos Amy |
| Affiliation: | Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama;, Department of Pediatrics, Sacred Heart Hospital, Pensacola, Florida;, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama;, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama;, Department of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, Alabama |
| Abstract: | Abstract: Adult T-cell leukemia/lymphoma is a T-cell malignancy caused by the human T-cell lymphotropic virus-I. Adult T-cell leukemia/lymphoma is primarily a disease of adults due to the long latency period between initial infection and development of leukemia. We present a case of acute adult T-cell leukemia/lymphoma in an adolescent. Skin lesions had appeared 3 years earlier and were the initial sign of human T-cell lymphotropic virus-I infection and T-cell malignancy. Her disease failed to respond to both intensive chemotherapy and antiviral therapy. Cutaneous lesions are sometimes the initial sign of adult T-cell leukemia/lymphoma and early recognition is imperative. |
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