| 中国东部汉族人群原发性胆汁性肝硬化与HLA-DRB1相关性分析 |
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| 引用本文： | 陈燕,周晔,邓安梅,陈波,蒋天舒,仲人前. 中国东部汉族人群原发性胆汁性肝硬化与HLA-DRB1相关性分析[J]. 中国免疫学杂志, 2006, 22(12): 1143-1145 |
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| 作者姓名： | 陈燕 周晔 邓安梅 陈波 蒋天舒 仲人前 |
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| 作者单位： | 第二军医大学附属长征医院临床实验诊断科、全军临床免疫中心,上海,200003 |
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| 摘 要： | 目的：探讨组织相容性抗原Ⅱ类HLA—DRB1等位基因与原发性肝汁性肝硬化（Primary biliary cirrhosis，PBC）患者人群的相关性。方法：采用序列特异性引物PCR（SSP．PCR）对105例确诊PBC患者，400例健康人群进行HLA-DRB1等位基因及相关亚型基因分析。结果：PBC患者组DRB1＊07的频率为37．26％，与正常人组的13．8％相比存在显著性差异（P〈0．05，比数比为2．7），所有阳性患者经亚型分析均为DRB1＊0701；其余DRB1的等位基因频率与正常对照组比较无显著性差异。DRB1＊0701阳性与阴性患者群体的疾病进程、临床指征、实验室指征等无显著性差异。绪论：中国人群PBC患者可能与DRB1＊0701易感性相关，为临床治疗提供了一定线索。
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| 关 键 词： | 原发性胆汁性肝硬化(PBC) 序列特异性引物聚合酶链反应 |
| 文章编号： | 1000-484X（2006）12-1143-03 |
| 收稿时间： | 2006-06-14 |
| 修稿时间： | 2006-06-142006-08-17 |
Susceptibility of DRB1 alleles in the east of Chinese people with primary biliary cirrhosis |
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| CHEN Yan,ZHOU Ye,DENG An-Mei,CHEN Bo,JIANG Tian-Shu,ZHONG Ren-Qian. Susceptibility of DRB1 alleles in the east of Chinese people with primary biliary cirrhosis[J]. Chinese Journal of Immunology, 2006, 22(12): 1143-1145 |
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| Authors: | CHEN Yan ZHOU Ye DENG An-Mei CHEN Bo JIANG Tian-Shu ZHONG Ren-Qian |
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| Affiliation: | Department of Clinical Diagnosis , Clinical Immunology Center of PLA , Changzheng Hospital, Shanghai 200003, China |
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| Abstract: | Objective:To study the susceptibility of HLA-DRB1 alleles in patients with primary biliary cirrhosis(PBC).Methods:Sequence specific primary polymerase chain high-resolution subtyping was applied.The susceptibility was analyzed statistically by SPSS software.Results:The frequence of DRB1*07 was increased by 37.26% compared with 13.8% in controls(P<0.05,OR=2.7) while frequencies for the other DRB1 alleles showed no significance.Conclusion:DRB1*0701 allele is related to PBC in Chinese people,especially for the eastern region,which is helpful for diagnosis and research for PBC further. |
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| Keywords: | HLA-DRB1 |
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