| IgA肾病尿液生物标记物的研究进展 |
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| 引用本文： | 付莎,徐安平. IgA肾病尿液生物标记物的研究进展[J]. 国外医学:内科学分册, 2009, 36(10): 610-613,617 |
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| 作者姓名： | 付莎 徐安平 |
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| 作者单位： | 中山大学附属第二医院肾内科,广州,510120;中山大学附属第二医院肾内科,广州,510120 |
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| 摘 要： | IgA肾病是全世界最常见的原发性肾小球疾病，是引起终末期肾功能衰竭的重要原因之一。IgA肾病以蛋白尿和（或）血尿为主要表现，病情变化轻重不一。大量研究显示多种炎症因子，细胞因子等参与了IgA。肾病病理损伤过程，其在尿液中的表达及变化在评估IgA肾病疾病活动性，检测疾病进展程度及评价疗效，评估预后等方面有重要意义。现就近年来对IgA肾病尿液生物标记物的研究进展作一综述。
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| 关 键 词： | IgA肾病 炎症因子 细胞因子 尿液生物标记物 |
Advancement of urinary biomarkers in IgA nephropathy |
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| FU Sha,XU An-ping. Advancement of urinary biomarkers in IgA nephropathy[J]. Foreign Medical Sciences(Section of Internal Medicine), 2009, 36(10): 610-613,617 |
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| Authors: | FU Sha XU An-ping |
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| Affiliation: | FU Sha,XU An-ping. Department of Nephrology,the Second Affiliated Hospital of Sun Yat-sen University,Guangzhou 510120,China |
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| Abstract: | IgA nephropathy has been recognized as the most common primary glomerulonephritis worldwide.Patients with IgA nephropathy usually manifest persistent hematuria and proteinuria clinically.To date,the diagnosis of IgA nephropathy as well as monitoring the clinical course of the disease requires invasive renal biopsy.Accumulating evidence indicates that various cytokines and growth factors may be involved in the progression of IgA nephropathy.The levels of urinary cytokines,proteins or peptides could reflect r... |
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| Keywords: | IgA nephropathy Inflammatory factor Cytokines Urinary biomarkers |
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