Immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum

Objective: To observe the immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum (CA). Methods: Thirty six CA patients were randomly divided into two groups, 19 in the treated group treated with lentinan and CO 2 laser irradiation, and 17 in the control group, treated with laser irradiation alone. Their T lymphocyte subsets of peripheral blood and level of serum interleukin 2 (IL 2) and soluble interleukin 2 receptor (SIL 2R) were determined before and after treatment, and the recurrence rates of the two groups were compared. Results: After treatment, in the treated group, the CD 4/CD 8 ratio, serum IL 2 raised and serum SIL 2R lowered significantly (P <0.05, 0.05, 0.05 respectively) as compared with before treatment, while those parameters were not changed significantly in the control group. The recurrence rate of the treated group was lower than that of the control group. P <0.05. Conclusion: Lentinan could modulate the cellular immunofunction of CA patients and reduce the recurrence rate of CA cases.