Immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum |
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Authors: | Yin Guangwen Yu Jianbin Li Dongqin He Fucheng Yin Huiqing Fu Shizhen |
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Affiliation: | 1. Department of Dermatology, The First Affiliated Hospital of Henan Medical University, 450052, Zhengzhou
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Abstract: | Objective: To observe the immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum (CA). Methods: Thirty six CA patients were randomly divided into two groups, 19 in the treated group treated with lentinan and CO 2 laser irradiation, and 17 in the control group, treated with laser irradiation alone. Their T lymphocyte subsets of peripheral blood and level of serum interleukin 2 (IL 2) and soluble interleukin 2 receptor (SIL 2R) were determined before and after treatment, and the recurrence rates of the two groups were compared. Results: After treatment, in the treated group, the CD 4/CD 8 ratio, serum IL 2 raised and serum SIL 2R lowered significantly (P <0.05, 0.05, 0.05 respectively) as compared with before treatment, while those parameters were not changed significantly in the control group. The recurrence rate of the treated group was lower than that of the control group. P <0.05. Conclusion: Lentinan could modulate the cellular immunofunction of CA patients and reduce the recurrence rate of CA cases. |
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Keywords: | Lentinan condyloma acuminatum immunomodulation treatment |
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