Solubility parameters from maxima in solubility/solvent plots |
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| Authors: | Guy Cavé Rohit Kothari F. Puisieux A.N. Martin J.T. Carstensen |
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| Affiliation: | 1. Faculté de Pharmacie, Laboratoire Galénique, Université de Paris-Sud, 92290 Châtenay-Malabry France;1. School of Pharmacy, University of Wisconsin, Madison, Wisc. 53706 U.S.A.;2. College of Pharmacy, University of Texas, Austin, Texas 78712 U.S.A. |
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| Abstract: | Solubility data of a substance in solvents with known solubility parameters have been used graphically in the past to determine the solubility parameter of the solute. A multiple regression method of handling this is presented. It gives rise to self-consistent solubility parameters, but the solvent molar volumes calculated are anomalous, pointing to the presence of factors not accounted for in the traditional approach to solubility parameter determination through solubility determination. |
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| Keywords: | To whom correspondence should be addressed. |
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