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| 大孔吸附树脂纯化两面针总生物碱 | |
| 引用本文： | 刘韶,章伟,雷鹏,李新中,梁逸曾.大孔吸附树脂纯化两面针总生物碱[J].中国中药杂志,2008,33(4):377-379. |
| 作者姓名： | 刘韶 章伟 雷鹏 李新中 梁逸曾 |
| 作者单位： | 1. 中南大学,湘雅医院,药剂科,湖南,长沙,410008;中南大学,中药现代化研究中心,湖南,长沙,410083 2. 湖南中医药大学,药学院,湖南,长沙,410004 3. 中南大学,湘雅医院,药剂科,湖南,长沙,410008 4. 中南大学,中药现代化研究中心,湖南,长沙,410083 |
| 基金项目： | 湖南省卫生厅中医药科研项目 |
| 摘 要： | 目的:研究大孔树脂分离和纯化两面针中总生物碱的工艺条件。方法:以总生物碱的吸附量和解吸率为考察指标,对8种不同类型的树脂进行评价。结果:XDA-5型大孔吸附树脂对两面针中总生物碱具有较好的分离能力。通过大孔树脂分离纯化后,终产品中总生物碱的纯度为33.25%,保留率达到90.15%。结论:采用本法分离纯化两面针中总生物碱是简单、可行的。 |
| 关 键 词： | 两面针 总生物碱 大孔吸附树脂 纯化 |
| 文章编号： | 1001-5302（2008）04-0377-03 |
| 收稿时间： | 2007-04-28 |
Separation and purification of alkaloids from radix of Zanthoxylum nitidum by macroporous adsorption resin |
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| LIU Shao ; ZHANG Wei ;LEI Peng ;LI Xin-zhong ;LIANG Yi-zeng.Separation and purification of alkaloids from radix of Zanthoxylum nitidum by macroporous adsorption resin[J].China Journal of Chinese Materia Medica,2008,33(4):377-379. | |
| Authors: | LIU Shao ; ZHANG Wei ;LEI Peng ;LI Xin-zhong ;LIANG Yi-zeng |
| Institution: | Department of Pharmacy, Xiangya Hospital, Center South University, Changsha 410008, China. liushao999@hotmail.com |
| Abstract: | Objective: To obtain the optimal conditions for separating the alkaloids from the extract of Radix of Zanthoxylum nitidum by selecting appropriate macroporous adsorption resins.Method:Eight types of macroporous adsorption were evaluated in separating efficiency with measuring the adsorption ratio and eluting ratio of Alkaloids as indexes. Result:The XDA-5 macroporous adsorption resin had the best separating efficiency.After enrichment and purification with it,the product purity and yield of alkaloids were up to 33.25 % and 90.15%,respectively.Conclusion:This method is simple,feasible and fit for industry production. |
| Keywords: | Zanthoxylum nitidum alkaloids macroporous adsorption resin purification |
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