| 盐酸贝那普利对糖尿病大鼠肾脏IGF-1表达及相关因素的影响 |
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| 引用本文： | 陈玉米,任伟,叶山东,邢燕,汪鹏,胡圆圆,胡闻,陈柯,陈燕.盐酸贝那普利对糖尿病大鼠肾脏IGF-1表达及相关因素的影响[J].安徽医科大学学报,2011,46(6):545-548. |
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| 作者姓名： | 陈玉米 任伟 叶山东 邢燕 汪鹏 胡圆圆 胡闻 陈柯 陈燕 |
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| 作者单位： | 安徽医科大学附属省立医院肾脏内科,合肥,230001;安徽医科大学附属省立医院内分泌科,合肥,230001;安徽医科大学附属省立医院病理科,合肥,230001;安徽医科大学附属省立医院内分泌实验室,合肥,230001 |
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| 摘 要： | 目的 观察盐酸贝那普利对糖尿病大鼠的肾脏保护作用及其可能机制.方法 将SD大鼠随机分为正常对照(NC)组和实验组.实验组通过一次性腹腔注射链脲佐菌素复制糖尿病大鼠模型.造模成功后,随机分为糖尿病(DM)组和贝那普利(DT)组,每周监测各组大鼠尾外周血血糖.4周后,检测糖化血红蛋白(HbA1c)及尿液中胰岛素样生长因子-...
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| 关 键 词： | 糖尿病 糖尿病肾病 胰岛素样生长因子Ⅰ |
Effect of benazepril hydrochloride on IGF-1 expression and related factors in diabetic rats |
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| Chen Yumi,Ren Wei,Ye Sh,ong,et al.Effect of benazepril hydrochloride on IGF-1 expression and related factors in diabetic rats[J].Acta Universitis Medicinalis Anhui,2011,46(6):545-548. |
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| Authors: | Chen Yumi Ren Wei Ye Sh ong |
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| Institution: | Chen Yumi1,Ren Wei1,Ye Shandong2,et al(1Dept of Nephrology,2Dept of Endocrinology,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001) |
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| Abstract: | Objective To investigate the renoprotective effects of benazepril hydrochloride and its possible mechanisms.Methods 30 Sprague-Dawley(SD)rats were assigned to normal control(group NC,n=8)and model group.Streptozotoin(STZ)-induced diabetic model rats were then treated with(group DM)or without benazepril(group DT).Peripheral blood glucose was tested weekly in all groups.At the end of the 4th week,blood glucose,HbA1c,urinary insulin-like growth factor-1(IGF-1),urinary albumin,and urinary retinol-binding protei... |
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