| 川芎嗪对单个心室肌细胞电生理的影响 |
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| 引用本文： | 陈江斌,黄从新,唐其柱.川芎嗪对单个心室肌细胞电生理的影响[J].武汉大学学报(医学版),1999,20(2):3. |
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| 作者姓名： | 陈江斌 黄从新 唐其柱 |
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| 作者单位： | The Laboratory of Cardiovascular Diseases，First Affiliated Hospital，Hubei Medical University，Wuhan 430060，China |
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| 摘 要： | 采用全细胞膜片钳（Ｗｈｏｌｅｃｅｌｌｐａｔｃｈ ｃｌａｍｐ） 技术研究川芎嗪（ 四甲基吡嗪，ｔｒｔｒａｍｅｔｈｙｌｐｙｒａｚｉｎｅ，ＴＭＰ） 对豚鼠心室肌细胞Ｌ型钙通道电流（Ｌ ＩＣａ）的浓度依赖性影响。当维持电位为－ ４０ ｍ Ｖ，刺激频率为０－５ Ｈｚ，钳制时间为４００ ｍｓ，步进电压为１０ ｍ Ｖ，去极到６０ ｍＶ，发现３ μｍｏｌ／ＬＴＭＰ对Ｌ ＩＣａ无影响（Ｐ＞ ０－０５） ；１０ ，３０ 和１００ μｍｏｌ／ＬＴＭＰ对Ｌ ＩＣａ的抑制为３６－３４ ％ ，５８－９４ ％ 和７４－２４％ （Ｐ均＜ ０－０１） ，且浓度愈大，其抑制作用愈强，但都不使Ｉ Ｖ曲线的峰值发生偏移。提示ＴＭＰ具有阻断Ｌ ＩＣａ的作用，且呈浓度依赖性阻滞效应。
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| 关 键 词： | 川芎 钙通道 心肌/药物作用 |
Electrophysiologic Effect of Trtramethylpyrazine on Ventricular Myocardium |
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| Chen Jiangbin,Huang Congxin,Tang Qizhu,et al.Electrophysiologic Effect of Trtramethylpyrazine on Ventricular Myocardium[J].Medical Journal of Wuhan University,1999,20(2):3. |
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| Authors: | Chen Jiangbin Huang Congxin Tang Qizhu |
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| Abstract: | The concentration dependent effects of trtramethylpyrazine (TMP) on the L type calcium channel(L I Ca ) of ventricular myocardium were studied with the whole cell patch clamp technique.When the holding potential was -40 mV, cells were depolarized to 60 mV for 400 ms with steps of 10 mV at frequency of 0.5 Hz,TMP 3 μmol/L did not affect L I Ca ( P >0.05), TMP 10,30 and 100 μmol/L reduced L I Ca by 36.34%、58.94%and 74.24%( P all <0.01),respectively,without shifting the current voltage(I V) curve for the peak L I Ca , and the more concentration of TMP, the more inhibitor effects to L I Ca .It is concluded that the TMP inhibited L I Ca in a concentration dependently manner. |
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| Keywords: | ligustici chuanxiong calcium channels myocardium/DE |
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