低分子肝素钙对川崎病高凝状态的影响

目的:观察低分子肝素钙对川崎病高凝状态的影响。方法:检测低分子肝素皮下注射治疗组和对照组患儿用药前后血小板(PL)、D鄄二聚体(D鄄D)、部分活化凝血酶时间(APTT),并观察低分子肝素钙的副作用。结果:治疗前两组比较,PL、D鄄D、APTT均无显著差别(P均>0.05)。治疗后治疗组PL、D鄄D下降显著低于对照组(P均<0.01),而APTT则显著延长(P<0.01),但在正常范围。低分子肝素钙皮下注射未发现出血现象。结论:低分子肝素钙可显著改善川崎病的高凝状态。

Effect of low molecule weight heparin on the high coagulation of Kawasaki disease

Objcetive: To study the effect of low molecule weight heparin (LMWH) on the high coagulation of Kawasaki disease (KD). Methods: The levels of platele t (PL), D-2-dimer (D-D) and activated partial thromboplastin time (APTT) of chil dren with KD were respectively measured before and after therapy in LMWH treatme nt group and control group. Results: PL, D-D and APTT were not significantly dif ferent in two groups before therapy and after therapy the first two items were a pperently lower, the late was significantly higher in treatment group than those in control group. The side-effect of bleeding was not found in the period of LM WH therapy. Conclusion: LMWH can improve the coagulation of KD.