湖南省高血压防治10年对脑血管意外疗效评估

高血压防治的目的是达到有效的降低脑血管意外的发生率和病死率。本研究为单盲随机多中心临床试验。分两阶段：第一阶段（１９８５年１月至１９８９年１２月）观察病例９８４例，时间５年；第二阶段（１９９０年１月至１９９４年１２月）观察２０８０例，随机分为治疗组和对照组，时间５年。结果表明高血压患病率呈上升趋势；第二阶段治疗组经尼群地平治疗后血压均值下降，与对照组和第一阶段组比较有统计学意义（Ｐ＜０．０５）。脑血管意外的发生率和病死率较对照组和第一阶段组均明显下降（Ｐ＜０．０１）。在各类死因中，脑血管意外所占比例较其他两组下降明显，且脑血管意外的病因构成发生了变化。从而提出积极开展高血压防治是降低高血压并发症脑血管意外发生和死亡的重要环节。

PREVENTION AND TREATMENT OF STROKE AFTER HYPERTENSION FOR TEN YEARS IN HUNAN PROVINCE

In this single blind, randomized multiple center clinical trial, the patients care period was divided into two stages. In the first stage (1985, 1-1989, 12), 984 cases were observed for 5 years whereas in the second stage (1990, 1-1994, 12), 2080 cases were observed and were subdivided into two groups, treat group and control, both were followed up for 5 years. The results showed that the prevalence of hypertension increased gradually. In the second stage, the average of blood pressure of the treatment group, using nitrendipine, was lower than that of the control group. There was significant difference between the two groups (P < 0.05). In the treatment group, the stroke and death rates were also decreased significantly as compared with the control group and the first stage group (P < 0.01).