旋覆代赭汤治疗脾胃虚弱型糖尿病胃轻瘫临床观察

目的:观察旋覆代赭汤在糖尿病胃轻瘫(Diabetic gastroparesis,DGP)患者促胃肠动力作用量-效关系研究。方法:将108例脾胃虚弱型患者随机分为治疗组:大剂量54例(一两为15.625g)和对照组剂量54例(一两为3g),对照组;治疗组药物口服旋覆代赭汤,每日1剂,连用4周。免疫组化法观察治疗前后血浆中P物质(substance P,SP)、血管活性肠肽(vasoactive intestnal peptide,VIP)的分布变化以及治疗前后各组胃电图变化。结果:治疗组血浆中SP、VIP的表达明显减少(P<0.01)、治疗前后各组胃电图变化有统计学意义(P<0.01),且组间餐后正常慢波百分比有统计学意义(P<0.05)。结论:旋覆代赭汤的促胃肠动力作用可能与血浆中SP和VIP的表达降低有密切关系,量-效关系明显。

Observation of Clinical Effect of Xuanfu Daizhe Decoction on Treating Diabetic Gastroparesis Due to the Weakness of Spleen and Stomach

Objective：To observe and research on the relationship between quantity of Xuanfu Daizhe Decoction and the clinical effect on its function of improving DGP＇s gastrointestinal motility.Methods：108 DGPs were randomly divided into treatment group and comparison group with 54 cases in each.Treatment group with more dose（1 Liang equals 15.625g）,comparison group with less dose（1 Liang equals 3g）;both groups adopt oral administration,1 dosage a day for consecutively 4 weeks.The changes of SP and VIP（in plasmas）distribution and changes of electrogastrogram before and after the treatment were detected by IHCA Method.Results：SP and VIP expressions in plasma were decreased obviously（P〈0.01）in the treatment group,electrogastrogram changes before and after the treatment had statistical meaning（P〈0.01）,and the percentage of normal slow waves after meals had statistical meaning（P〈0.05）.Conclusion：The function of Xuanfu Daizhe Decoction on improving gastrointestinal motility may have close relationship with SP and VIP expressions in plasma,and the dose-effect relation is obvious.