| 从细胞因子研究雷公藤多苷致大鼠卵巢功能低下模型的中医证候属性 |
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| 引用本文： | 曹俊岩,范宏元,曾莉,吴克明. 从细胞因子研究雷公藤多苷致大鼠卵巢功能低下模型的中医证候属性[J]. 辽宁中医杂志, 2012, 0(11): 2282-2283 |
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| 作者姓名： | 曹俊岩 范宏元 曾莉 吴克明 |
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| 作者单位： | 贵阳中医学院;成都中医药大学 |
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| 基金项目： | 教育部高等学校博士学科点专项科研基金(20095132110009);四川省教育厅资助项目(10zc053) |
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| 摘 要： | 目的:探讨雷公藤致卵巢储备功能下降大鼠模型的中医证候属性。方法:用雷公藤多苷片造成雌性卵巢功能低下大鼠模型,通过以方测证观察新加归肾丸、圣愈汤、逍遥散、丹溪治湿痰方对大鼠卵巢组织IGF-1R、VEGF及Flk-1表达的影响。结果:各用药组中新加归肾丸组3项指标最接近于正常组。结论:补肾中药复方治疗的有效性在一定程度上证实了该大鼠模型符合中医肾虚证候属性。
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| 关 键 词： | 雷公藤多苷(GTW) 卵巢功能低下 动物模型 以药测证 中医证候属性 |
Study of TCM Syndrome Differentiation of DOS in Rat Model Caused by GTW from View of Cell Factors |
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| CAO Jun-yan,FAN Hong-yuan,ZENG Li,WU Ke-ming. Study of TCM Syndrome Differentiation of DOS in Rat Model Caused by GTW from View of Cell Factors[J]. Liaoning Journal of Traditional Chinese Medicine, 2012, 0(11): 2282-2283 |
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| Authors: | CAO Jun-yan FAN Hong-yuan ZENG Li WU Ke-ming |
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| Affiliation: | 1.Guiyang University of Traditional Chinese Medicine,Guiyang 550001,Guizhou,China; 2.Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China) |
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| Abstract: | Objective：To approach the TCM syndrome differentiation of DOS in rat model caused by GTW.Methods：Female rat DOS model was established by GTW.The effect of Xinjia Guishen pill was evaluated by IGF-1R,VEGF and Flk-1.Results：IGF-1R,VEGF and Flk-1of Xinjia Guishen pill group were the most close to those in normal group.Conclusion：The effectiveness of treatment with the herbal compound for tonifying kidney verifies the rat model has the TCM syndrome of kidney deficiency. |
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| Keywords: | GTW DOS animal model syndrome determination by medicine TCM syndrome differentiation |
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