Multiple organ failure (MOF) after severe trauma — A sheep model |
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| Authors: | H. C. Pape M. Grotz D. Remmers A. Dwenger R. Vaske D. Wisner H. Tscherne |
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| Affiliation: | (1) Department of Trauma Surgery, Hannover Medical School, Carl Neubergstr. 1, D-30625 Hannover, Germany Tel.: +49 51 15 32 20 50 Fax: +49 51 15 32 58 77, DE;(2) Department of Clinical Biochemistry Hannover Medical School, Carl Neubergstr. 1, D-30625 Hannover, Germany, DE;(3) Department of Veterinary Pathology, Hannover Medical School, Carl Neubergstr. 1, D-30625 Hannover, Germany, DE;(4) Department of Surgery, University of California, Davis, Sacramento, USA, US |
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| Abstract: | Objective: To perform a reproducible long-term (10 days) large animal model of multiple systems organ failure without necessity of a continuous stimulus. Design: Adult female merino sheep submitted to a 5-day stimulation period followed by a 5-day observation period. Day 1: Hemorrhagic shock was combined with a traumatic surgical insult (reamed intramedullary femoral nailing), followed by serial administrations every 12 h for 5 days of a combination of endotoxin and zymosan activated plasma. Organ function was followed for 5 further days. Results: Cardiac index increased significantly during the study (day 1: 491 ± 8 mm Hg; day 10: 427 ± 20, p < 0.05). Liver function was impaired and bilirubin levels increased significantly (day 1: 2.9 ± 0.3 μmol/l; day 10: 7.2 ± 0.9; p < 0.05). Creatinine clearance decreased initially (day 1: 54 ± 7 ml/min), increased to a peak on day 2 (104 ± 27), and then deteriorated again (day 10: 53 ± 18). Conclusion: This new large animal model of trauma-induced MOF is reproducible and may be suitable for the study of new therapeutic approaches to therapy. Received: 15 September 1997 Accepted: 3 March 1998 |
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| Keywords: | Large animal model Multiple organ failure Zymosan activated plasma Endotoxin Intramedullary femoral nailing |
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