Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice |
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| Authors: | Fu, Peter P. Dooley, Kenneth L. Von Tungeln, Linda S. Bucci, Thomas Hart, Ronald W. Kadlubar, Fred F. |
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| Affiliation: | National Center for Toxicological Research Jefferson, AR 72079, USA |
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| Abstract: | Caloric restriction (CR) inhibited strongly the incidence ofchemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicitybioassay, when begun 3 months after treatment with the potentcarcinogen 6-nitrochrysene. These data indicate that CR canhave a profound inhibitory effect on tumor development evenlong after metabolic activation and DNA repair have occurred. |
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