| 多药耐药基因MDR1多态性的研究进展 |
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| 引用本文： | 徐萍,李焕德. 多药耐药基因MDR1多态性的研究进展[J]. 中国临床药理学杂志, 2006, 22(6): 464-467 |
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| 作者姓名： | 徐萍 李焕德 |
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| 作者单位： | 中南大学,湘雅二医院,临床药学研究室,湖南,长沙,410011 |
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| 摘 要： | MDR1所编码的P-糖蛋白是ABC蛋白家族成员之一,它在体内药物的转运和处置中发挥着重要作用。本文就近几年有关MDR1基因多态性对P-糖蛋白在组织中表达的影响、以及MDR1多态性对药物处置、临床疗效以及疾病风险等影响进行综述。
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| 关 键 词： | 多药耐药基因 P-糖蛋白 单核苷酸多态性 药物转运体 |
| 文章编号： | 1001-6821（2006）06-0464-04 |
| 收稿时间： | 2005-08-09 |
| 修稿时间： | 2006-04-28 |
Advance in search for polymorphisms in human multidrug resistance 1 gene |
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| XU Ping,LI Huan-de. Advance in search for polymorphisms in human multidrug resistance 1 gene[J]. The Chinese Journal of Clinical Pharmacology, 2006, 22(6): 464-467 |
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| Authors: | XU Ping LI Huan-de |
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| Affiliation: | Department of Clinical Pharmacy, The Second Xiangya Hospital of Central South University, Changsha 410011, China |
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| Abstract: | The multidrug resistance 1 gene (MDR1) gene product P-glycoprotein (P-gp)is a member of ATP-binding cassette transports. P-gp is recognized to be important in drug disposition and response since it express in certain tissues and the broad substrate specificity. Recently, a number of single-nucleotide polymorphisms (SNPs) in MDR1 have been identified. However, the reported effects of MDR1 SNPs on P-gp expression and transport activity have been inconsistent and, in some case, conflicting. In this review SNPs in MDR1 in relation to population frequencies, P-gp tissue expression, drug disposition, treatment outcome and disease risk are discussed. |
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| Keywords: | multidrug resistance 1 gene P-glycoprotein single nucleotide polymorphism drug transporters |
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