Surgical Management of the Colorectal Cancer Patient with Simultaneous Liver and Lung Metastases

Although the liver and lung are the two most common sites of metastatic disease for colon and rectal cancer, management of simultaneous liver and lung metastases is ill-defined. The objective of this review is not only to review long-term outcomes after resection of simultaneous colorectal liver and lung metastases but also apply recent data regarding the (1) evolution of indeterminate pulmonary nodules discovered during staging evaluation of colorectal liver metastases, (2) impact of genetic mutations in colorectal cancer on disease outcomes, and (3) influence of lung metastases on overall survival outcomes to the management of patients with simultaneous colorectal liver and lung metastases.