Cardiovascular Complications of HIV in Endemic Countries |
| |
| Authors: | Matthew J. Feinstein Milana Bogorodskaya Gerald S. Bloomfield Rajesh Vedanthan Mark J. Siedner Gene F. Kwan Christopher T. Longenecker |
| |
| Affiliation: | 1.Division of Cardiovascular Diseases, Department of Medicine,Northwestern University Feinberg School of Medicine,Chicago,USA;2.Department of Medicine, Case Western Reserve University School of Medicine,Cleveland,USA;3.Department of Medicine,University Hospitals Case Medical Center,Cleveland,USA;4.Division of Cardiology, Department of Medicine, Duke Clinical Research Institute,Duke University,Durham,USA;5.Zena and Michael A. Wiener Cardiovascular Institute,Icahn School of Medicine at Mount Sinai,New York,USA;6.Division of Infectious Diseases, Department of Medicine,Massachusetts General Hospital,Boston,USA;7.Section of Cardiovascular Medicine, Department of Medicine,Boston University School of Medicine,Boston,USA;8.Division of Cardiology, Department of Medicine,University Hospitals Case Medical Center,Cleveland,USA |
| |
| Abstract: | Effective combination antiretroviral therapy (ART) has enabled human immunodeficiency virus (HIV) infection to evolve from a generally fatal condition to a manageable chronic disease. This transition began two decades ago in high-income countries and has more recently begun in lower income, HIV endemic countries (HIV-ECs). With this transition, there has been a concurrent shift in clinical and public health burden from AIDS-related complications and opportunistic infections to those associated with well-controlled HIV disease, including cardiovascular disease (CVD). In the current treatment era, traditional CVD risk factors and HIV-related factors both contribute to an elevated risk of myocardial infarction, stroke, heart failure, and arrhythmias. In HIV-ECs, the high prevalence of persons living with HIV and growing prevalence of CVD risk factors will contribute to a growing epidemic of HIV-associated CVD. In this review, we discuss the epidemiology and pathophysiology of cardiovascular complications of HIV and the resultant implications for public health efforts in HIV-ECs. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
