美沙酮维持治疗门诊受治人群HCV感染及影响因素分析

目的：了解西安市美沙酮维持治疗门诊受治人群丙型肝炎病毒（HCV）感染现状及其特点，为制订相应的干预措施提供科学依据。方法：对西安市美沙酮维持治疗门诊（MMT）2007年5月1日至2008年5月31日入组的404名海洛因依赖者进行问卷调查，并采静脉血检测抗-HCV抗体。结果：404名吸毒者中，抗-HCV阳性率为60．6％。静脉注射史中，曾静脉注射吸毒者280人，抗-HCV阳性率为75．4％，高于非静脉吸毒者的27．4％，差异有统计学意义（P〈0．01）。有14人曾共用注射器具，占3．5％（14／404）。共用注射器具的感染率为78．6％。未共用注射器具者的HCV感染率为60．0％。多性伴者HCV感染率明显高于单一性伴或无性伴者．P〈0．01．有统计学意义。结论：西安市海溶因依籁人群HCV感染率高．相关危险行为普谝存在。

Analysis of influencing factors of HCV infection in drug users from methadone maintenance therapy clinic in Xi'an

Objective： To describe the characteristics of HCV infection among drug users of xian, and provide baseline data for valid intervention. Methods： Face-to-face interview with detailed questionnaire was conducted amongst 404 drug users in the methadone maintenance therapy （MMT） clinic of Xian,and blood sample was collected and tested for HCV antibody. Results： The overall anti-HCV antibody-positive rate was 60.6%,while the rate was75.4 % among 280 IDUs, significantly higher than that of NIDUs （27.4%, Х^2=10.26,P〈0.01）. 3.5% （14/404） had shared syringes and needles with other IDUSo A significantly higher HCV infection rate was found among drug users who have more than 1 sex partner, compared with those who have single or no sex partner. Conclusion： High HCV infection rate was observed among drug users in MMT clinic of Xiani,and behaviors at high risk were commonly identified.