New chromosome rearrangement in acute lymphoblastic leukemia |
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Authors: | Gündüz Cumhur Co?ulu Ozgür Cetingül Nazan Kantar Mehmet Cankaya Tufan Ozkinay Cihangir Ozkinay Ferda |
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Institution: | Department of Medical Biology, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey. |
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Abstract: | Cytogenetic findings in leukemia can be used in the diagnosis, prognosis, and in the definition of different subgroups. The most common chromosome abnormalities associated with mature B-cell acute lymphoblastic leukemia (ALL) are t(8;14), t(8;22), t(2;8), and partial duplication of 1q. Various abnormalities involving chromosome 1 have also been reported in ALL. We present a 16-year-old male with mature B-cell ALL whose cytogenetic analysis of bone marrow showed the karyotype of 46,XY,t(8;14)(q24;q32), -15,der(1;15)(p10;q10). The case presented here carries one of the most common abnormalities, t(8;14) (q24;q32), and a new rearrangement, der(1;15)(p10;q10), which has not been described to date in mature B-cell ALL. |
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