Modification of Retinyl Acetate Toxicity in Rats by Coadministration of Menhaden Oil

Modification of Retinyl Acetate Toxicity in Rats by Coadministrationof Menhaden Oil. LLN DAMOOD, C., III, THIGPEN, L. M., GILES,H. D., MAKOVEC, G. T., MCCARTHY, D. J., AND) HILL, D. L. (1989).Fundam. Appl. Toxicol. 12, 567–578. Menhaden oil, whichhas hypolipidemic and anticarcinogenic activity, reduces thehypertriglyceridemia caused by retinyl acetate. Male Sprague-Dawleyrats were dosed daily for 30 days by gavage with either cornoil (CO); menhaden oil (MO); 20, 80, and 250 mg/kg retinyl acetate(ROAc) in CO; or 20,80, or 250 mg/kg ROAc in MO. Hypertriglycendemiaby ROAc was reduced by coadministration of MO, and serum cholesterolvalues were reduced to levels similar to those for rats receivingMO alone. Coadministration of MO reduced the ROAc-induced fractureincidence at 80 mg/kg but not at 250 mg/kg; For groups dosedwith ROAc and CO or MO, there were no differences in weight-gaindepression, elevation of serum alkaline phosphatase, or reductionof food consumption, suggesting that reduced absorption of ROAcwas not the basis for the activity of MO. The reduction in retinoidtoxicity by MO suggests a need for further study of the toxicityand anticarcino genicity of retinoid/menhaden oil combinations.