CD147和FGF-2在鼻咽癌中的表达及临床意义

目的探讨基质金属蛋白酶刺激因子（CD147）和成纤维细胞生长因子-2（FGF-2）在鼻咽癌中的表达及临床意义。方法采用免疫组织化学法检测81例鼻咽癌组织及43例鼻咽慢性炎症组织中CD147与FGF-2的表达．并分析其与临床病理特征和淋巴结转移的关系。结果肿瘤组织中CD147、FGF．2的阳性表达率均显著高于正常对照组织，差异有统计学意义（P〈0．05）；CD147、FGF-2的阳性表达率在有淋巴结转移组均显著高于无淋巴结转移组，且与CD147、FGF-2二者的表达呈正相关（r=0．387，P〈0．05）。结论CD147、FGF-2的高表达可能在鼻咽癌的发生、发展中起一定的促进作用。

Expression of CD147 and FGF-2 in nasopharyngeal carcinoma and the clinical significance

Objective To investigate the expression of extracellular matrix metalloproteinase inducer （CD147） and the fibroblast growth factor 2（FGF-2） in nasopharyngeal carcinoma and the clinical significance. Methods Immunohistochemical straining（SP） method was adopted for detecting the expression of CD147 and FGF-2 in 81 patients with nasopharyngeal carcinoma and 43 patients with normal tissues to analyze the relationship between clinicopathologic characteristics and lymph node metastasis. Results The positive expression rates of CD147 and FGF-2 in carcinoma tissue were prominently higher than those in the normal tissue with statistically significant difference （P〈0.05）. The positive expression rates of CD147 and FGF-2 in the group with lymphatic metastasis were prominently higher than those in the group without lymphatic metastasis, and the expression of CD147 and FGF-2 is positively correlated with each other（P〈0.05）. Conclusion The high expression of CD147 and FGF-2 plays a positive role in the occurrence and development of nasopharyngeal carcinoma.