| 线粒体DNA与细胞癌变关系研究进展 |
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| 引用本文： | 胡义德,钱桂生,郑颂国,曹世龙. 线粒体DNA与细胞癌变关系研究进展[J]. 中国癌症杂志, 2000, 10(1): 90-92 |
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| 作者姓名： | 胡义德 钱桂生 郑颂国 曹世龙 |
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| 作者单位： | 1. 第三军医大学新桥医院全军呼吸内科研究所,重庆,400037
2. 上海医科大学附属肿瘤医院,上海,200032 |
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| 基金项目： | 国家自然科学基金项目(编号:39500173). |
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| 摘 要： | 人类细胞线粒体ＤＮＡ（ｍｉｔｏｃｈｏｎｄｒｉａｌ ＤＮＡ，ｍｔＤＮＡ）是一具有１６５６９个碱基对的双链闭环分子，它包含２２个ｔＲＮＡ和２个ｒＲＮ基因，并编码１３个有关细胞线粒体氧化磷酸化的蛋白多肽。与核ＤＮＡ相比，ｍｔＤＮＡ分子更容易受致癌物的损伤。提示细胞质遗传与核遗传系统共同参与了细胞癌变过程。本综述重点讨论ｍｔＤＮＡ损伤与突变在细胞癌变中的地位和可能的作用机制。
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| 关 键 词： | 线粒体DNA 细胞癌变 mtDNA损伤 |
| 文章编号： | 1007-3639(2000)01-0090-03 |
| 修稿时间： | 1999-04-02 |
Research advances in relationship between mitochondrial DNA and carcinogenesis of mammalian cells |
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| HU Yi de,QIAN Gui sheng,ZHENG Song guo,et al.. Research advances in relationship between mitochondrial DNA and carcinogenesis of mammalian cells[J]. China Oncology, 2000, 10(1): 90-92 |
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| Authors: | HU Yi de QIAN Gui sheng ZHENG Song guo et al. |
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| Abstract: | Human mitochondrial DNA (mtDNA) is a 16?569 base pair double stranded,closed circular molecule,which codes for two ribosomal RNAs,22 transfer RNAs and 13 proteins. All of the mitochondrial genes encode subunits of the oxidative phosphorylation (OXPHOS) enzymes that are responsible for the energy generating pathway. mtDNA is thought to be more susceptible to damage by mutagens than nuclear DNA. This implies that both nuclear and cytoplasmic elements are responsible for the steps of carcinogenesis.So,in this article,we reviewed the relationship between mtDNA and carcinogenesis of mammalian cells. The possible mechanisms were also discussed. |
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| Keywords: | mitochondrial DNA mammalian cell carcinogenesis |
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