| 药代动力学建模的人工神经网络新方法 |
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| 引用本文： | 刘朝晖,李明亚,黄榕波.药代动力学建模的人工神经网络新方法[J].中国临床药理学杂志,2008,24(4). |
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| 作者姓名： | 刘朝晖 李明亚 黄榕波 |
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| 作者单位： | 1. 广东约学院,中药药理教研室,广州,510006
2. 广东约学院,数学教研室,广州,510006 |
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| 摘 要： | 人工神经网络(ANN)在药代动力学领域主要用于血药浓度预测、药物结构和药代动力学定量关系、体内体外相关关系研究,群体药物动力学数据分析、药代动力学-药效动力学统一模型研究等。本文就ANN的基本理论及其在药代动力学研究的应用作简要综述。
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| 关 键 词： | 人工神经网络 药代动力学 |
Artificial neural network:a new method in pharmacokinetic modeling |
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| LIU Zhao-hui,LI Ming-ya,HUANG Rong-bo.Artificial neural network:a new method in pharmacokinetic modeling[J].The Chinese Journal of Clinical Pharmacology,2008,24(4). |
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| Authors: | LIU Zhao-hui LI Ming-ya HUANG Rong-bo |
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| Institution: | LIU Zhao-hui1,LI Ming-ya1,HUANG Rong-bo2 |
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| Abstract: | Artificial neural network (ANN) is applied in the pharmacokinetics, such as the prediction of drug blood levels , quantitative structure-pharmacokinetic relationships,in vitro-in vivo correlation, population pharmacokinetic data analysis and pharmacokinetic -pharmacodynamic link models analysis. In this paper, the basic theory and the application in pharmacokinetics of ANN is reviewed. |
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| Keywords: | artificial neural network pharmacokinetics |
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