不同方式建成3种反流性食管炎模型

运用贲门成形＋幽门结扎＋胃空肠Ｒｏｕｘ－ｅｎ－Ｙ吻合术，全胃切除＋食管十一指肠吻合术，及单屯食十二指肠吻合术，分别制作 单纯胃液食管反流（Ｇ）、单纯十二指肠内容物食管反流（Ｄ）及十二指肠胃内容物混合食管反流（ＤＧ）３种大鼠模型。于不同病程分批取得食管标本进行组织形态学研究。

STUDY ON ANIMAL MODELS OF DIFFERENT REFLUX ESOPHAGITIS

In order to investigate the role of different reflux in pathogenesis of gastroesophageal reflux disease (GERD), rat models of reflux esophagitis were established. Three kinds of model were made by different opera- tions, which were gastroesophageal reflux(G), duodenoesophageal reflux(D) and duodenogastro- esophageal reflux (DG). The esophageal samples were taken at different time after operation and studied. Most of the rats in all re- flux groups displayed evidence of reflux esophagitis,which was more severe in lower part of esophagus than in up- per part,and more severe with postoperation time. The main histologic changes were inflammation, erosion, ulcer and epithelial cell hyperplasia. Esophageal mucosa injury was most severe in D group, then in DG group and sligh-test in G group. These results suggest that models of reflux esophagitis can be successfully made by different oper- ating methods. Both of gastric juice and duodenal contents, refluxing into esophageal alone or simultaneously, can injury esophageal mucosa seriously. The effect of duodenal contents is stronger and it may play an important role in the pathogenesis of GERD and its complications.