| 17β-雌二醇抑制刀豆蛋白A诱导的胸腺细胞增殖能力 |
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| 引用本文： | 姚根宏,商学军. 17β-雌二醇抑制刀豆蛋白A诱导的胸腺细胞增殖能力[J]. 医学研究生学报, 2005, 18(7): 588-590 |
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| 作者姓名： | 姚根宏 商学军 |
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| 作者单位： | 南京大学医学院临床学院(南京军区南京总医院) 生殖遗传研究室,江苏南京,210002 |
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| 摘 要： | 目的：通过研究雌激素对细胞免疫力的调节作用，探讨雌激素的免疫调节功能。方法：用单四唑(MTr)法检测10^-8、10^-7和10^-6moL／L的雌激素在体外对刀豆蛋白A(ConA)刺激的胸腺细胞增殖能力。结果：三种浓度的雌激素组与对照组相比，胸腺细胞的增殖能力均受到抑制，其抑制效应有剂量和时间依赖性。结论：雌激素对细胞免疫力有抑制作用。
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| 关 键 词： | 雌激素 胸腺细胞 增殖 细胞免疫 |
| 文章编号： | 1008-8199(2005)07-0588-03 |
| 修稿时间： | 2005-03-16 |
17β-estradiol inhibit proliferation of thymocytes induced by ConA |
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| YAO Gen-hong,SHANG Xue-jun. 17β-estradiol inhibit proliferation of thymocytes induced by ConA[J]. Bulletin of Medical Postgraduate, 2005, 18(7): 588-590 |
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| Authors: | YAO Gen-hong SHANG Xue-jun |
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| Abstract: | Objective: The effects of estrogen on cellular immunity were investigated to explore the immunomodulatory properties of estrogen. Methods: In the present study, the in vitro influences of estrogen at 10~(-8),10~(-7 )and 10~(-6) mol/L on the ConA-induced proliferation of thymocytes were determined by MTT assay. Results: The results showed that estrogen at all concentrations we used suppressed the ConA-induced proliferation of thymocytes. The inhibitive effects had dose- and time- dependent pattern. Conclusion: These results suggested that estrogen had inhibiting effects on the cellular immunity. |
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| Keywords: | Estrogen Thymocyte Proliferation Cellular immunity |
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