Altered expression levels of G protein subclass mRNAs in various seizure stages of the kindling model |
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Authors: | Iwasa H Kikuchi S Miyagishima H Mine S Koseki K Hasegawa S |
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Institution: | Department of Neuropsychiatry, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260, Japan. iwasa@med.m.chiba-u.ac.jp |
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Abstract: | The expressions of mRNAs encoding G protein alpha subunits were analyzed in the cerebral cortex of amygdaloid kindled rats. A remarkable increase in Gsalpha mRNA were observed on the bilateral cerebral cortex at 24 h after the last generalized seizure and persisted 3 weeks on the unstimulated side. Gi2alpha mRNA level was also increased on the stimulated side at 24 h and persisted 3 weeks. These result suggest that dysfunction of Gs and Gi2 might relate to the basic mechanisms of seizure generation and the maintenance of epileptogenesis. |
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Keywords: | Epilepsy G protein Gi2 mRNA Gs mRNA Kindling Signal transduction system |
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