Transmission blocking antibody of the Plasmodium falciparum zygote/ookinete surface protein Pfs25 also influences sporozoite development |
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| Authors: | A.H.W. LENSEN G.J.A. VAN GEMERT M.G. BOLMER J.F.G.M. MEIS D. KASLOW J.H.E. Th. MEUWISSEN T. PONNUDURAI |
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| Affiliation: | Department of Parasitology, University of Nijmegen, The Netherlands. |
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| Abstract: | The Plasmodium falciparum zygote/ookinete surface protein, Pfs25, persists in the oocyst wall throughout its development. Anti-25 kD transmission blocking antibody, given to infected Anopheles stephensi or A. gambiae mosquitoes in an additional bloodmeal, 3-6 days after being fed gametocyte infected blood, penetrated the oocyst and reacted with the 25 kD protein within it. This reaction caused a significant reduction in the number of developing sporozoites. Mouse serum containing antibodies raised by immunization with a recombinant 25 kD yeast product showed a similar effect. |
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| Keywords: | malaria Plasmodium falciparum transmission blockade sporozoites |
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