Pharmacokinetic evaluation of single-dose intravenous daptomycin in patients with thermal burn injury |
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Authors: | Mohr John F Ostrosky-Zeichner Luis Wainright David J Parks Donald H Hollenbeck Timothy C Ericsson Charles D |
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Affiliation: | Division of Infectious Diseases, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 2.112, Houston, Texas 77030, USA. john.mohr@uth.tmc.edu |
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Abstract: | Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to achieve drug exposures similar to those for healthy volunteers receiving 6 mg/kg. |
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