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| 熊果酸醇质体的制备和体外透皮研究 | |
| 引用本文： | 陈彦,吴青青,张振海,周蕾,刘璇,杜萌,贾晓斌.熊果酸醇质体的制备和体外透皮研究[J].中国中药杂志,2011,36(8):988-991. |
| 作者姓名： | 陈彦 吴青青 张振海 周蕾 刘璇 杜萌 贾晓斌 |
| 作者单位： | 1. 江苏大学,药学院,江苏,镇江,212013;国家中医药管理局,中药释药系统重点研究室,江苏省中医药研究院,中药新型给药系统重点实验室,江苏,南京,210028 2. 江苏大学,药学院,江苏,镇江,212013 3. 国家中医药管理局,中药释药系统重点研究室,江苏省中医药研究院,中药新型给药系统重点实验室,江苏,南京,210028 |
| 基金项目： | 江苏省中医药领军人才项目(LJ200913) |
| 摘 要： | 目的:制备熊果酸醇质体并考察醇质体作为熊果酸经皮给药载体的渗透特性.方法:采用乙醇注入法制备熊果酸醇质体,并对其形态及粒径进行分析;采用TP-3型透皮扩散实验仪进行体外透皮吸收试验,比较熊果酸10%异丙醇溶液、熊果酸醇质体、熊果酸脂质体的经皮累积渗透量和渗透速率.结果:此方法制得的醇质体平均包封率为(95.83±0.86)%,平均粒径为(87.5±7.5)nln,Zata电位为-(38.4±3.6)mV.醇质体12 h的累积透过量为146.49μg·cm-2,12 h的渗透速率为12.17μg·cm-2.h-1.结论:醇质体包封率高,稳定性好,可显著促进熊果酸的透皮吸收. |
| 关 键 词： | 熊果酸 醇质体 体外透皮 |
| 收稿时间： | 2010/10/14 0:00:00 |
Preparation and transdermal diffusion of ursolic acid ethosomes |
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| CHEN Yan,WU Qingqing,ZHANG Zhenhai,ZHOU Lei,LIU Xuan,DU Meng and JIA Xiaobin.Preparation and transdermal diffusion of ursolic acid ethosomes[J].China Journal of Chinese Materia Medica,2011,36(8):988-991. | |
| Authors: | CHEN Yan WU Qingqing ZHANG Zhenhai ZHOU Lei LIU Xuan DU Meng and JIA Xiaobin |
| Institution: | Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China |
| Abstract: | Objective: To prepare ursolic acid ethosomes and investigate the penetration characteristics of ursolic ethosomes as a transdermal vehicle.Method: Ursolic acid ethosomes were prepared by injection method,and the shape and particle size of the ethosomes were analyzed.Ursolic acid permeation tests in vitro through the skin of rats were performed in TP-3 diffusion cell.The accumulated permeation amounts of ursolic acid 10% isopropanol solution,ursolic acid liposomes,ursolic acid ethosomes were compared.Result:... |
| Keywords: | ursolic acid ethosomes transdermal diffusion in vitro |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |