固定正畸对成人和青少年患者龈沟液中AST活性影响的研究

目的:通过检测龈沟液中天冬氨酸转氨酶(AST)的活性来评价固定正畸对成人和青少年牙周健康的影响。方法:随机选择口腔正畸科门诊34例青少年患者、36例成人患者,测定矫治前后1个月时间内11、13、31、33颊舌侧及23近远中侧龈沟液中AST的活性,探讨其变化规律及其在两个年龄组变化的差异。结果:1)成人组13、31、23近中及23远中牙位在矫治开始前和四周后AST活性的比较均有显著性差异(P<0.05)。2)13牙位AST活性的比较均为成人组高于青少年组,其差别有统计学意义(P<0.05):其中成人4周后和青少年4周后AST活性的比较(P<0.01)。3)青少年组矫治1个月之后,龈沟液中AST活性略有升高但其差别无统计学意义;而成人组矫治1个月之后,龈沟液中AST活性有明显升高,其差别有统计学意义(P<0.05)。结论:固定正畸对成人和青少年患者龈沟液中AST活性的影响不同,成人与青少年正畸治疗起始阶段对正畸力的反应存在着增龄性差异。

GCF-AST Activity between Adult and Adolescent during Fixed Orthodontic Treatment

Objective: To Study the AST activity in gingival crevicular fluid(GCF) and to evaluate the influence of periodontal healthiness between adult and adolescent during the fixed orthodontic treatment.Methods: Thirty-four adolescent patients and thirty-six adult patients were selected in this study.The buccuolingual GCF-AST activity of right maxillary incisor(11),right maxillary canine(13),left mandibular incisor(31),left mandibular canine(33) and the mesiobuccal distobuccal GCF-AST activity of left maxillary canine(23) were measured before appliance activation(APA) and after twenty-eight days(TED).Then the regulation and difference of the AST activity between adult and adolescent were explored.Results: 1) The AST activity between APA and TED was statistically significant(P<0.05) at adult's bucclingual sites of 11,13,31 or at adult's mesiobuccal and distobuccal sites of 23.2) The adult's AST activity was significantly greater than that of adolescent both on APA and TED.Particularly,the AST activity on TED between adult and adolescent was statistically significant(P<0.01).3) No statistically significant difference was found in adolescent's mean AST activity between APA and TED.But the adult's mean AST activity on TED was significantly elevated as compared with APA.Conclusion: The influence of GCF-AST activity between adult and adolescent was different.During the original orthodontic treatment,adult's and adolescent's reaction to orthodontic fore was different.