| FOLFOX4方案治疗晚期大肠癌疗效观察 |
| |
| 引用本文： | 王鹏远,赵宏亮.FOLFOX4方案治疗晚期大肠癌疗效观察[J].医药论坛杂志,2010(7). |
| |
| 作者姓名： | 王鹏远 赵宏亮 |
| |
| 作者单位： | 河南省许昌市中心医院肿瘤科; |
| |
| 摘 要： | 目的评价FOLFOX4方案治疗晚期大肠癌的疗效与安全性。方法按FOLFOX4方案给药,奥沙利铂85mg/m2,静脉滴注2h,第1d;CF200mg/m2,静脉滴注2h,第1,2d;5-FU400mg/m2,于CF滴完后静脉注射10min,第1,2d;5-FU600mg/m2,持续泵入22h,第1,2d;每2~3周重复。结果入组观察48例,可评价疗效者48例,其中CR5例(10.4%),PR14例(29.2%),CR+PR共19例,近期客观有效率39.6%;SD 20例(41.7%),PD 9例(18.8%)。中位TTP 9.3个月,中位OS 22.4个月。不良反应主要为白细胞减少,消化道不良反应较轻,较明显的毒副反应为周围神经毒性,无化疗相关死亡。结论FOLFOX4方案治疗晚期大肠癌癌疗效较高,不良反应轻而且安全。
|
| 关 键 词： | 大肠癌 化疗 奥沙利铂 亚叶酸钙 5-氟尿嘧啶 |
Clinical Research of FOLFOX4 in Treatment of Advanced Colorectal Cancer |
| |
| WANG Pengyuan,ZHAO Hongliang.Clinical Research of FOLFOX4 in Treatment of Advanced Colorectal Cancer[J].Journal of Medical Forum,2010(7). |
| |
| Authors: | WANG Pengyuan ZHAO Hongliang |
| |
| Institution: | WANG Pengyuan,ZHAO HongliangDepartment of Oncology,Xuchang Central Hospital,Xuchang 461000,China |
| |
| Abstract: | Objective To evaluate the efficiency and toxicity of the chemotherapy regimen FOLFOX4 for the patient with advanced colorectal cancer.Methods Oxaliplatin 85 mg/m2 i.v.over 2 hours,day 1,Leucovorin 400mg/m2 i.v.over 2 hours,days 1 and 2,5-FU 400mg/m2 i.v.bolus,then 600mg/m2 i.v.over 22 hours continuous infusion,days 1 and 2,Repeat every 2 or 3 weeks.Results Totally 48 patients with advanced colorectal cancer entered the study.Among them 5 patients reached complete response(CR),14 partial response(PR).The ove... |
| |
| Keywords: | Colorectal cancer Chemotherapy Oxaliplatin Leucovorin 5-fluorouracil |
| 本文献已被 CNKI 等数据库收录！ |
|
