Na+ entry and modulation of Na+/Ca2+ exchange as a key mechanism of TRPC signaling |
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| Authors: | Petra Eder Michael Poteser Christoph Romanin Klaus Groschner |
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| Institution: | (1) Institute of Pharmaceutical Sciences, Pharmacology and Toxicology, Karl-Franzens-University of Graz, Universitaetsplatz 2, 8010 Graz, Austria;(2) Institute of Biophysics, University of Linz, 4020 Linz, Austria |
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| Abstract: | Ion channels formed by canonical transient receptor potential (TRPC) proteins are considered to be key players in cellular Ca2+ homeostasis. As permeation of Ca2+ through TRPC homo- and/or heteromeric channels has been repeatedly demonstrated, analysis of the physiological role of TRPC proteins was so far based on the concept that these proteins form regulated Ca2+ entry channels. The well-recognized lack of cation selectivity of TRPC channels and the ability to generate substantial monovalent conductances that govern membrane potential and cation gradients were barely appreciated as a physiologically relevant issue. Nonetheless, recent studies suggest monovalent, specifically Na+ permeation through TRPC cation channels as an important event in TRPC signaling. TRPC-mediated Na+ entry may be converted into a distinct pattern of cellular Ca2+ signals by interaction with Na+/Ca2+ exchanger proteins. This review discusses current concepts regarding the link between Na+ entry through TRPC channels and cellular Ca2+ signaling. |
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| Keywords: | TRPC proteins Non-selective cation channels Ca2+ signaling Na+/Ca2+ exchange |
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