| 参蟾消解胶囊质量标准研究 |
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| 引用本文： | 贺梅,;易珊,;刘燕,;杨琴,;马恒,;管丽娜,;于亮亮.参蟾消解胶囊质量标准研究[J].中国药房,2009(36):2846-2848. |
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| 作者姓名： | 贺梅 ;易珊 ;刘燕 ;杨琴 ;马恒 ;管丽娜 ;于亮亮 |
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| 作者单位： | [1]贵州省毕节地区医院,毕节市551700; [2]吉林省中医药科学院,长春市130012; [3]长春中医药大学,长春市130117 |
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| 摘 要： | 目的:建立参蟾消解胶囊的质量标准。方法:采用薄层色谱(TLC)法对方中蟾酥、人工牛黄、冰片、芦荟、西红花进行定性鉴别;采用高效液相色谱法对制剂中脂蟾毒配基进行含量测定。结果:TLC斑点清晰、分离度好、专属性强、阴性无干扰。脂蟾毒配基进样量在0.28368～1.41840μg范围内与峰面积积分值呈良好线性关系(r=0.9999);平均回收率为97.67%,RSD=1.29%(n=6)。结论:所建标准可用于参蟾消解胶囊的质量控制。
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| 关 键 词： | 参蟾消解胶囊 薄层色谱法 高效液相色谱法 质量标准 |
Quality Criteria of Shenchan Xiaojie Capsules |
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| Institution: | HE Mei,YI Shan, LIU Yan, YANG Qin,MA Heng, GUAN Li-na, YU Liang-liang(1Guizhou Provincial Bijie District Hospital, Bijie 551700, China;2Jilin Academy of Chinese Medicine Sciences, Changchun 130012, China;3Changchun University of Traditional Chinese Medicine, Changchun 130117, China) |
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| Abstract: | OBJECTIVE： To establish the quality criteria of Shenchan xiaojie capsules. METHODS： TLC was employed to identify Venenum Bufonis,Calculus Boris Artifactus, Borneolum Syntheticum, Aloe, and Crocus sativus, while the content of resibufogenin in Shenchan xiaojie capsules was determined by HPLC. RESULTS： The TLC spots were clear, well- separated and specific yet without interference from negative control. The linear range of resibufogenin was 0.283 68-1.418 40μ（ r = 0. 999 9） with an average recovery rate of 97.67% （RSD = 1.29 %, n = 6）. CONCLUSION： The established criteria is suitable for the quality control of Shenchan xiaojie capsules. |
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| Keywords: | Shenchan xiaojie capsules TLC HPLC Quality criteria |
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