夫西地酸钠治疗耐甲氧西林金黄色葡萄球菌骨科感染的疗效观察

目的:比较夫西地酸钠与万古霉素治疗耐甲氧西林金黄色葡萄球菌(MRSA)骨科感染的临床疗效。方法:86例MRSA感染患者随机分为治疗组(46例)与对照组(40例),分别给予夫西地酸钠、万古霉素治疗,均采用静脉滴注给药。记录2组的疗效、细菌清除率及药品不良反应。结果:治疗组与对照组的总有效率分别为91.3%、92.5%(P>0.05),细菌清除率分别为87.0%、87.5%(P>0.05)。治疗组无明显不良反应发生,对照组不良反应发生率为7.5%。结论:夫西地酸钠治疗MRSA骨科感染效果与万古霉素相当,且其不良反应较少。

Clinical Efficacy of Sodium Fusidate for Orthopedic Patients Infected with Methicillin - resistant Staphy-ococcus Aureus

OBJECTIVE： To evaluate the efficacy of Sodium Fusidate versus vancomycin for orthopedic patients infected with methicillin-resistant Staphylococcus aureus （MRSA） . METHODS： A total of 86 MRSA-infected patients were randomly assigned to receive Sodium Fusidate （trial group, n = 46） or vancomycin （control group, n = 40） by iv gtt. The clinical efficacy, bacterial clearance rate, and adverse reactions of the two groups were recorded. RESULTS： In the trial group versus the control group, the total effective rate was 91.3% vs. 92.5% （P 〉 0.05）, the bacterial clearance rate was 87.0% vs. 87.5% （P 〉 0.05）, and adverse drug reaction was none in the trial group vs. 7.5% of the control group. CONCLUSIONS; Sodium Fusidate is as effective as vancomycin but has fewer side effects for orthopedic patients infected with MRSA.