载脂蛋白B基因多态性对阿托伐他汀调脂疗效的影响 |
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引用本文: | 范蕾,;宋洪涛,;盖晓波,;夏向南.载脂蛋白B基因多态性对阿托伐他汀调脂疗效的影响[J].中国药房,2009(32):2529-2531. |
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作者姓名: | 范蕾 ;宋洪涛 ;盖晓波 ;夏向南 |
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作者单位: | [1]南京军区福州总医院药学科,福州市350025; [2]沈阳药科大学药学院,沈阳市110016; [3]南京军区福州,总医院心血管内科,福州市350025; [4]南京军区福州,总医院老年一科,福州市350025 |
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摘 要: | 目的:观察载脂蛋白B(ApoB)基因多态性对低剂量阿托伐他汀调脂疗效的影响。方法:选择高脂血症患者211例,其中67例服用阿托伐他汀10mg,每晚1次;于治疗前及治疗开始后第4、8、12周抽血实验室检查血脂指标。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLPs)方法检测ApoB基因XbaⅠ酶切位点基因多态性。结果:211例高脂血症患者中,X+等位基因相对频率为0.0853,X-等位基因相对频率为0.9147。服用阿托伐他汀4周后,携带X+X-基因型患者的总胆固醇(TC)降低百分率较X-X-基因型患者少(14.98%vs.19.39%,P<0.05)。结论:阿托伐他汀对携带X+等位基因的高脂血症患者的调脂疗效减弱。
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关 键 词: | 载脂蛋白B 基因多态性 高脂血症 阿托伐他汀 |
Effects of Polymorphism of Apolipoprotein B Gene on Lipid - regulating Efficacy of Atorvastatin |
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Institution: | FAN Lei, SONG Hong-tao, GAI Xiao-bo, XIA Xiang-nan(Dept. of Pharmacy, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, China) FAN Lei(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;2.Dept. of Cardiology,Fuzhou General Hospital of Nanjlng Military Command, Fuzhou 350025, China;3.First Dept. of Geriatrics, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, China) |
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Abstract: | OBJECTIVE: To evaluate the effect of polymorphism in Apo B gene on the lipid regulating efficacy of low dose of atorvastatin. METHODS: 221 patients with hyperlipidemia were enrolled, of whom, 67 were treated with oral atorvastatin (10 mg.d^-1) quaque nocte. The blood lipid indexes were measured before treatment and at 4, 8 and 12 weeks of treatment. The polymorphisms of Apo B gene on Xba Ⅰlocus were determined using PCR RFLPs method. RESULTS: Of the 211 patients, the relative frequency of X + allele and X- allele were 0.085 3 and 0.914 7, respectively. After treatment with atorvastatin for 4 weeks, the TC reduction in X + X - genotype carriers was less than in X - X - genotype carriers (14.98% vs. 19.39%, P (0.05) . CONCLUSION: Atorvastatin attenuates the lipid- regulating efficacy in hyperlipidemia patients carrying X + allele. |
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Keywords: | Apolipoprotein B Gene polymorphism Hyperlipidemia Atorvastatin |
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