别嘌醇不良反应文献及临床案例分析

目的:了解别嘌醇不良反应发生的总体趋势、特点及相关因素。方法:检索1991～2008年《中国期刊全文数据库》有关别嘌醇不良反应的文献及我院临床案例,并进行汇总、分析、比较。结果:符合卫生部药品不良反应诊断标准的文献共76篇、77例,其中死亡10例(12.99%);临床案例共67例,其中死亡2例(2.99%),死亡率较高。皮肤黏膜损伤最常见,占90%以上,主要表现为药疹与发热,且往往伴有多个器官或系统同时受累。结论:临床上使用别嘌醇时应加强其不良反应监测。

Literature Review of Allopurinol and Analysis of Allopurinol - induced Adverse Reactions

OBJECTIVE： To probe into the tendency, characteristics and correlation factors of the allopurinol induced adverse drug reactions（ADR） METHODS： The literature related to allopurinol - induced ADR retrieved from CNKI （between 1991 and 2008） as well as the allopurinol - induced clinical ADR cases collected in our hospital were summarized, analyzed and compared. RESULTS： A total of 77 ADR cases（reported in 76 papers） met the diagnostic criteria of ADR specified by Ministry of Public Health were collected, of which, 10 cases（12.99% ） died. A total of 67 clinical cases were collected from our hospital, of which, 2 cases（2.99% ） died, showing a high mortality rate. Mucocutaneous lesion was the chief ADR type, accounting for more than 90%, and the ADR chiefly appeared as drug rash and febrile and multiple organs or systems were often involved in the ADR. CONCLUSION： It is important to enhance ADR monitoring in clinical use of allopnrinol.