柞蚕蛹虫草提取物对模型大鼠膜性肾炎的保护作用研究

目的:研究柞蚕蛹虫草提取物对模型大鼠膜性肾炎的保护作用。方法:以阳离子化牛血清白蛋白复制大鼠膜性肾炎模型。第3周末起每周测定1次24h尿蛋白,实验结束时测定尿蛋白含量、血液流液学、血肌酐、尿素氮、血脂水平,观察治疗效果。结果:柞蚕蛹虫草提取物可降低模型大鼠尿蛋白含量、全血黏度、血肌酐、尿素氮和血脂水平,能延缓肾脏病变的进程。结论:柞蚕蛹虫草提取物有改善肾脏功能的作用。

Therapeutic Effect of Extracts from Cordyceps militaris on Membranous Nephritis Model Rats

OBJECTIVE： To explore the therapeutic effect of the extracts from Cordyceps militaris on membraneous nephritis model rats. METHODS： Membraneous nephritis model rats were induced by using cationic bovine serum albumin.3 weeks later, urine protein quantity （24 h） was determined weekly; at the end of experiment, the hemorheology, serum creatinine （Scr）, blood urea nitrogen （BUN） and serum lipid level were examined and the therapeutic efficacy was evaluated. RESULTS： C. militaris -treatment reduced urine protein quantity （24 h）,blood viscosity, serum creatinine （Scr）, blood urea nitrogen （BUN） and serum lipid level and delayed the progress of renal lesions. CONCLUSION： Extracts of C.militaris has the action of improving renal function.