甘草酸表面修饰N-己酰化壳聚糖纳米粒的制备及其稳定性研究 |
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引用本文: | 林爱华,;陈军,;刘奕明,;平其能.甘草酸表面修饰N-己酰化壳聚糖纳米粒的制备及其稳定性研究[J].中国药房,2009(36):2824-2826. |
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作者姓名: | 林爱华 ;陈军 ;刘奕明 ;平其能 |
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作者单位: | [1]广州中医药大学第二临床医学院,广州市510120; [2]南京中医药大学药学院,南京市210029; [3]中国药科大学药学院,南京市210009 |
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基金项目: | 广东省自然科学基金项目(04010047) |
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摘 要: | 目的:制备N-己酰化壳聚糖纳米粒(CCS-NPs)和甘草酸表面修饰N-己酰化壳聚糖纳米粒(CCS-NPs-GL),并考察其稳定性。方法:应用离子凝胶法制备CCS-NPs,高碘酸盐氧化法制备CCS-NPs-GL;考察各纳米粒在冷冻干燥前、后和不同pH缓冲盐中粒径、电位的变化以及不同温度对CCS-NPs-GL的粒径、药物包封率和甘草酸结合率的影响。结果:CCS-NPs和CCS-NPs-GL在冷冻干燥后粒径稍有增大,缓冲盐溶液中迅速分散,电位下降不明显;在生理pH条件下,两者易于分散且粒径无明显变化;不同温度下,CCS-NPs-GL的粒径、药物包封率和甘草酸结合率无明显变化。结论:CCS-NPs-GL作为潜在的肝靶向主动传输载体,其粒子的稳定性可满足后续静脉给药的体内靶向研究和药效学评价。
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关 键 词: | N-己酰化壳聚糖 纳米粒 甘草酸 表面修饰 稳定性 |
Preparation of N - caproyl Chitosan Nanoparticles Surface - modified with Glycyrrhizin and Its Stability in Vitro |
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Institution: | LIN Ai-hua,LIU Yi-ming,CHEN Jun, PING Qi-neng(1The Second Clinical Medical College, Guangzhou University of TCM, Guangzhou 510120, China;2School of Pharmacy, Nanjing University of TCM, Nanjing 210029, China;3School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China) |
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Abstract: | OBJECTIVE: To prepare N- caproyl chitosan nanoparticles(CCS- NPs) and N- caproyl chitosan nanoparticles surface- modified with glycyrrhizin(CCS- NPs GL) and study its stability. METHODS: CCS NPs were prepared hy ionic gelation method and CCS - NPs - GL was obtained though periodate oxidation method. The particle size, zeta potential before and after freeze- drying at different pH value were investigated. The particle size, drug encapsulation efficiency and glycyrrhizin binding ratio of CCS- NPs- GL was investigated at different temperatures.RESULTS: The particle size increased, well - dispersed in salt solution, zeta potential drop was not obvious after freeze - drying. In physiological pH medium, both CCS- NPs and CCS NPs - GL were easy to disperse and had no significant change in particle size. No significant change was noted for CCS - NPs - GL of the particle size, drug encapsulation efficiency and glycyrrhizin binding ratio indifferent temperatures.CONCLUSION: CCS- NPs- GL, as a potential initiative drug carrier, its particle stability can satisfy the research on its intravenously hepatoeyte- targeted delivery and pharmacodynamic evaluation. |
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Keywords: | N - caproyl chitosan Nanoparticles Glycyrrhizin Surface modification Stability |
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