冠脉搭桥围术期3种抗菌药物预防性应用比较

目的:比较冠脉搭桥围术期预防性应用3种抗菌药物控制感染情况及抗菌药物费用支出情况。方法:84例冠脉搭桥患者分为3组,各28例,术后分别应用美洛西林钠、头孢呋辛钠和环丙沙星,对照观察其感染情况、体温变化、白细胞变化、抗菌药物费用等指标。结果:3组患者术后均无感染发生,但头孢呋辛钠组呼吸机支持时间最短((14.21±5.45)h),平均抗菌药物费用最低((678.28±256.74)元),与其他2组比较差异均有统计学意义(P<0.05)。结论:冠脉搭桥患者术后应用头孢呋辛钠,可满足预防术后感染的需要,并可节约医疗费用。

Prophylactic Use of Three Kinds of Antimicrobials for Patients Undergoing Coronary Artery Bypass Graft

OBJECTIVE： To analyze the utilization and cost of three kinds antibiotics in patients undergoing coronary artery bypass graft （CABG） . METHODS： Eight four CABG patients were divided into three groups： Mezlocillin Sodium group （n = 28）, Cefuroxime Sodium group （n = 28） and Ciprofloxacin group （n = 28） . The postoperative infection rate, changes in body temperature WBC count and the cost of antibiotics were compared among the 3 groups. RESULTS： No postoperative infection case was noted in all. the 3 groups, The duration for breathing machine used in Cefuroxime sodium group was the shortest at （ 14.21 ± 5.45） hours, and the average cost for antibiotics in this group was also the lowest at （678.28± 256.74） yuan, showing significance as compared with the other two groups （P 〈 0.05）. CONCLUSION： The use of Cefuroxime Sodium in patients after undergoing coronary artery bypass graft can prevent the patients from postoperative infection and help save medical resources.