我院90例药品不良反应报告分析

目的:分析2008年度我院药品不良反应(ADR)监测情况,促进临床用药合理及安全。方法:对我院2008年1～12月临床各科呈报的ADR病例,按国家ADR监测中心制定的标准进行描述、因果关系分析评价、分级、汇总及统计。结果:90例ADR监测报告中,涉及药品50种,由抗菌药物引起的疑似ADR最为常见,共48例(占53.33%);由降压药、抗心绞痛药引起的疑似ADR其次,有11例(占12.22%);再者是由中药制剂引起的疑似ADR,有6例(占6.67%);由静脉滴注引起的疑似ADR也是所有给药途径中最为多见的,有72例(占80.00%);ADR的临床表现以皮肤及其附件损害最为多见,有38例(占42.22%)。结论:我院抗菌药物所引起的ADR相对较多,应正确合理使用,并予以关注。

Analysis of Adverse Drug Reactions Reported in 2008 by Our Hospital

OBJECTIVE： To analyze the adverse drug reactions（ADR） occurred in our hospital in 2008 and to promote clinical rational and safe medication. METHODS： The ADR case reports submitted by your hospital between Jan. and Dec. in 2008 were described in accordance with the standard set by State ADR Monitoring Center, evaluated about the causal relation, graded, collected and statistically analyzed. RESULTS： 50 kinds of drugs were involved in the 90 ADR cases monitored, leading the list were antibiotics which caused 48 （53.33%） suspicious ADR cases, followed by hypotensive drugs and antianginal drugs which induced 11（12.22% ） suspicious ADR cases and Chinese medicine preparations which induced 6（6.67% ） suspicious ADR cases. The suspected ADR cases induced by intravenous route were most common, accounting for 80.00% （72 cases） ; lesions of skin and its appendants were most common clinical manifestations of ADR, which accounted for 42.22% （38 cases） . CONCLUSION： The incidence of ADR induced by antibiotics was on the high side; therefore, great attention should be given to the rational use of antibiotics.