咪康唑氯霉素乳膏对豚鼠皮肤的安全性评价

目的:评价咪康唑氯霉素乳膏对豚鼠皮肤的安全性。方法:将空白基质、阳性致敏物(2,4-二硝基氯苯)和高、低剂量的咪康唑氯霉素乳膏等相应药物用于豚鼠背部完整或破损受试皮肤,分别进行皮肤急性毒性试验、过敏试验和刺激性试验。结果:咪康唑氯霉素乳膏应用于豚鼠皮肤上,未见急性毒性反应;反复致敏后使用也未见皮肤与全身过敏反应;一次或多次给药均对豚鼠完整皮肤无刺激性,而对破损皮肤有轻度刺激性,但给药后48h或72h该刺激性消失。结论:本品用于豚鼠皮肤安全性较好。

Derma Safety of Miconazole and Chloramphenicol Cream for Guinea Pigs

OBJECTIVE： To evaluate the derma safety of mieonazole and chloramphenicol cream （MCC） for Guinea pigs. METHODS： Blank matrix, positive sensitizing agent （2, 4- dinitro-chlorobenzene） and MCC （high dose and low dose） were applied on normal or damaged areas of the unhairing backs of Guinea pigs to conduct acute toxicity test, sensitivity test and irritation test, respectively. RESULTS： MCC caused no acute toxicity when applied on the skin of Guinea pigs, nor skin/ systemic hypersensitive reaction was noted after repeated sensitization. Single or multiple dosing of MCC caused no irritation on normal skin of Guinea pigs but caused mild irritation on damaged skin which disappeared after 48 h or 72 h. CONCLUSION： MCC has good dermo safety for Guinea pigs.