3种用药方案治疗膝骨关节炎的成本-效果分析

目的:探讨不同用药方案治疗膝骨关节炎的经济效果。方法:选取膝骨关节炎共116例的临床资料,根据用药的种类分为3组,即A组塞来昔布胶囊200mg,每日1次,疗程28d;B组在A组基础上加用双氯芬酸二乙胺乳胶剂2支;C组在A组基础上加用辣椒碱软膏4支。按照Lyshol m膝关节评分系统,评价患者治疗前、后改善情况,并进行成本-效果分析。结果:A、B、C组治疗成本分别为206.97、252.77、298.53元,总有效率分别为61.54%、71.05%、84.62%,成本-效果比分别为336.32、355.76、352.79;在A组的基础上,B组和C组增量成本-效果比分别为481.60、396.71。结论:C组较A组的总有效率有明显提高,而且获得单位效果所需成本明显低于B组。因此,C组是较为合理的用药方案。

Cost - Effectiveness Analysis of Three Therapeutic Schemes for Knee Osteoarthritis

OBJECTIVE： To evaluate the economic effects of different therapeutic schemes for knee osteoarthritis. METHODS： The clinical data of 116 patients with knee osteoarthritis were divided into three groups, namely, Group A （taking Celebrex 200 mg q.d for 28 days） ; Group B （Celebrex 200 mg daily orally plus topically application of Diclofenac diethylammonium） ; and Group C（Celebrex 200 mg daily orally plus topically application of 4 boxes of Capsacin ointment） . The improvement of knee osteoarthritis was evaluated by Lysholm rating system. And a cost - effectiveness analysis was conducted. RESULTS： The costs of Group A, B, and C were 206.97 yuan, 252.77 yuan and 298.53 yuan respectively; the effective rates were 61.54%, 71.05% and 84.62%, respectively; the cost- effectiveness ratios were 336.32, 355.76 and 352.79, respectively. The incremental cost- effectiveness ratios of Group B and C as against Group A were 481.60 and 396.71, respectively. CONCLUSION： In Group C compared Group A, the effective rate was significantly higher; and as compared with Group B, the cost for gaining each unit of effectiveness in Group C was significantly lower. Group C is the optimal one among the three schemes.