疏血通注射液治疗血管性痴呆的临床观察

目的:观察疏血通注射液治疗血管性痴呆(VD)的疗效。方法:将VD患者60例,随机分为治疗组和对照组。2组患者均接受基础治疗及护理,视病情严重程度及合并症给予降压、降糖、降脂等治疗。治疗组加用疏血通注射液6mL加入生理盐水250mL中静脉滴注,每日1次;对照组加用胞二磷胆碱注射液250mg加入生理盐水250mL中静脉滴注,每日1次。治疗时间均为21d。试验前、后分别进行MMSE、ADL量表和TCD、P300检查。结果:治疗组MMSE、ADL评分显著优于对照组(P<0.05);与对照组比较,治疗组脑血流显著加快(P<0.05),P300电位潜伏期显著缩短(P<0.05)、波幅显著升高(P<0.05)。结论:疏血通注射液能够安全有效地治疗VD。

Clinical Efficacy of Shuxuetong Injection for Vascular Dementia

OBJECTIVE： To study the curative efficacy of Shuxuetong injection for vascular dementia （VD）. METHODS： A total of 60 patients with VD were randomized to receive Shuxuetong injection （6 mL） added into normal saline （250 mL）q.d by drip infusion for 21 days （treatment group） or citicoline injection（250 mg） added into 250 mL normal saline q.d by drip infusion for 21 days （control group） . In addition, both groups received basic treatment and nursing care, and the antihypertensive, hypoglycemic and hypolipidemic therapies were adopted based on the patients＇ severity of disease and complications. The efficacy was evaluated before and after treatment by using minimental state examination（MMSE）, activities of daily living （ADL）, transcranial Doppler （TCD） and P300 test. RESULTS： Compared to control group, the treatment group had significantly higher MMSE score and ADL score（P 〈 0.05）, significantly accelerated cerebral blood flow （P 〈 0.05）, significantly shortened incubation period of P300 electric potential（P〈0.05）, and significantly higher wave amplitude（P〈0.05） CONCLUSION： Shuxuetong injection is safe and effective for patients with vascular dementia.