血管新生对动脉粥样硬化斑块稳定性影响的研究进展

斑块内血管新生由低氧和炎症等因素诱导形成,在动脉粥样硬化斑块的发生发展中发挥了重要作用。一方面通过加剧炎症反应和诱发斑块内出血,影响斑块的稳定性,从而诱发死亡率极高的急性冠状动脉综合征;另一方面可缓解斑块内低氧状态,减少细胞坏死,为斑块内有害物质的移出提供通道。抗血管生成治疗虽已投入临床应用,但在动脉粥样硬化方面进展甚小。本文就斑块内新生血管形成发生机制、血管新生对动脉粥样硬化斑块稳定性的影响及其相关临床应用进展作一综述。

Intraplaque Neovascularization and Its Influence on Stability of Atherosclerosis Plaque

Intraplaque angiogenesis induced by factors such as hypoxia and inflammation, plays a vital role in both occurrence and progression of atherosclerosis plaque. Not only the neovessels can undermine the stability of plaque by deteriorating inflammation and promoting intraplaque hemorrhage, which may lead to deadly acute coronary syndrome, the neovessels also can benefit the plaque by relieving oxygen, reducing cellular necrosis and providing a functional pathway to get deleterious substances out of the plaque. Although antiangiogenic therapy has been applied into clinical practice, treatment of plaques with angiogenesis are still well unanswered. This paper reviews the formation and progression of the angiogenesis in atherosclerosis, and summarizes the due effects of angiogenesis on the plaque stability and the current status of antiangiogenic therapy.