Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives |
| |
| Authors: | Manal M Kandeel Lamia W Mohamed Mohammed K Abd El Hamid Ahmed T Negmeldin |
| |
| Institution: | Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. |
| |
| Abstract: | A new series of pyrazolo3,4-d]pyrimidines has been synthesized. The new compounds were tested for their antitumor activity on 60 different cell lines, and some of the compounds were found to have potent antitumor activity. In particular, 2-hydroxybenzaldehyde 1-(4-chlorophenyl)-3-methyl-1H-pyrazolo-3,4-d]pyrimidin-4-yl]hydrazone (VIIa) was found to be the most effective among the other derivatives, showing IC50 values of 0.326 to 4.31 μM on 57 different cell lines. |
| |
| Keywords: | Pyrazolopyrimidines Antitumor Activity Cytotoxic Activity Synthesis |
|
|
