Relative Telomere Length and Stroke Risk in a Chinese Han Population |
| |
| Authors: | Dan Gao Rui Zhang Guofa Ji Chunqi Li Dangshe Guo Tianbo Jin Mingwei Chen |
| |
| Affiliation: | 1.Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,China;2.Department of Internal Medicine,Shaanxi Normal University Hospital,Xi’an,China;3.Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences,Northwest University,Xi’an,China |
| |
| Abstract: | This study aimed to further understand the role of relative telomere length (RTL) in susceptibility to stroke and investigate the association regulator of telomere elongation helicase 1 (RETL1) gene polymorphisms and RTL. RTL was measured using the real-time quantitative polymerase chain reaction (qPCR) from 300 stroke patients and 299 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. The results indicated that stroke patients had significantly shorter median RTL than controls (P?P?P?P??1.366). Stratified analysis showed that the shorter RTL was also significantly increased the risk of stroke compared with the longer RTL in male, age P?=?0.031) and AA (P?=?0.032), respectively. Our results suggested that shorter RTL was associated with an increased risk of stroke. The association was found between the genotypes AA (rs2297441) and GG (rs6089953) and shorter RTL in case group. Further studies in larger sample size and biological functional assays are warranted to validate our findings. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
