dl—萘普生重排合成的工艺研究 |
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引用本文: | 陈芬儿,董恩莲.dl—萘普生重排合成的工艺研究[J].中国医药工业杂志,1992,23(9):388-390. |
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作者姓名: | 陈芬儿 董恩莲 |
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作者单位: | 武汉化工学院制药研究室,武汉化工学院,武汉化工学院 湖北430074,湖北430074 化学制药专业1987级学生,湖北430074 化学制药专业1988级学生 |
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摘 要: | 以2-甲氧基萘为起始原料,通过丙酰化、溴化、缩酮化、重排及水解制成2-(5-溴-6-甲氧基-2-萘基)丙酸,再经催化转移氢解脱溴即得萘普生。工艺简便,反应条件温和,总收率达74%。
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关 键 词: | 萘普生 合成 工艺 药物学 |
SYNTHESIS OF dl-NAPROXEN BY 1,2-ARYL REARRANGEMENT |
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Authors: | CHEN Fen-Er DONG En-Lian SHAO Lan-Ying |
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Abstract: | A facile preparation of dl-naproxen,starting from 2-methoxyna-phthalene,via propionylation,bromination,ketalization,rearrangement and hy-drolysis as well as debromination with some improvements,is described.All re-actions were carried out in mild conditions and convenient work-up to afford dl-naproxen in about 74% overall yield. |
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Keywords: | naproxen catalytic transfer hydrogenolysis debromination synthesis |
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