以双铂为主方案治疗晚期恶性肿瘤41例报告

目的：评价双铂为主方案的耐受性，毒性和初步疗效。方法：自1998年10月起，以双铂为主方案治疗晚期恶性肿瘤41例。化疗方案以CBP＋PDD分别与Vp-16,Vm-26,CF,5-FU,CTX及ADM配伍。其中CBP 200－300mg iv第1天，PDD 40－50mg iv第3，4，5天。15例同时合并放疗。结果：全组共完成101个周期，中位周期数2。可评价疗效31例，可评价毒性41例。总有效率67．74％（21／31）。常见的毒副反应为骨髓抑制，发生率85．37％（35／41）。其中I度19．51％（8／41），Ⅱ度41．46％（17／41），Ⅲ度21．95％（9／41）。结论：双铂为主方案的疗效较好，耐受，毒副反应轻微。

Combined carboplatin and cisplatin mainly therapy in 41 patients with advanced cancer

Objective:To evaluate the tolerability, toxicity and preliminary effect of combined carboplatcn (CBP) and cisplatin (PDD) mainly regimen. Methods:From Oct. 1998 to Mar. 2000, 41 cases with advanced cancers were treated by combined CBP and PDD mainly regimen. 15cases of them were treated with radiotherapy meanwhile. CBP 200~300mg iv drip on day 1, PDD 40 -50mg iv drip on day 3, 4, 5. Combined with Vp-16, Vm-26, CF, 5-Fu, CTX and ADM individually. The treatment repeated every 3-4 weeks. Results: 101 cycles were finished in the whole group, middle cycles was 2. 31 cases could indentified effects and 41 cases could indentified toxicities. Myelosuppression was the main toxicity, The overall response rate was 67.74% (21/31), among them, NSCLC 54.6% (6/11), SCLC 100% (5/5), esophageal cancer 100% (7/7) . Conclusion; Combined carboplatin and cisplatin mainly regimen is associated with good tolerability, low toxicity and satisfied preliminary effect. It is worthy going to a step further research.