肺癌患者血清维生素A及β-胡萝卜素水平与免疫功能关系的研究

测定了三组58人(肺癌22,肺部常见病14,健康人22)的血清VA、β-胡萝卜素、IgA、IgG、IgM三种免疫球蛋白和T-淋巴细胞转化率。结果发现,肺癌患者(除5例腺癌)的血清VA含量明显低于健康组和肺部常见病组。三组对象的β-胡萝卜素平均含量在正常值范围,若以三组平均值为界限,肺癌和肺部常见病者低于平均值的比例高于健康组。各组间血清IgG无差别,肺癌组和肺部常见病组的IgA明显高于健康组,肺癌组IgM和T-淋巴细胞转化率明显低于健康组。血清VA类与Ig的相关分析表明,健康人血清VA水平与血清IgM呈负相关,肺癌组血清VA与血清IgG呈正相关。

STUDY ON SERUM VITAMIN A, BETA-CAROTENE AND IMMUNE FUNCTION IN LUNG CANCER

Serum vitamin A, beta-carntene and lgG, IgA, IgM and T-lymphocyte Mastogenesis were measured in lung cancer patients, nonmalignant lung, disease and healthy controls matched lor age, sex and smoking. Mean serum vitamin A of lung cancer (except 5 adenocarcinoma) was significantly lower than that of healthy controls and non-malignant lung disease. Beta-caroiene levels were within the normal range, but mean serum beta-carotene concentration oi lung cancer patients was 24.7% lower, IgA of lung career and non-malignant lung disease patients was significantly higher, IgM and the rate of T-lymphocy te, blastogenesis of patients with lung cancer were lower than that of healthy controls, respectively. Serum IgG was not significant in 3 groups. An inverse relation, between serum vitamin A and IgM of hcalthy controls and arelation between serum vitamin A and IgG of lung cancer patients were observed. These data demonstrate an influence of vitamin A on immune function in lung cancer patients.