Modeling and parameter estimation of yeast size distribution dynamics |
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Authors: | Paul J. Palatt Gerald M. Saidel |
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Affiliation: | 1. Department of Biomedical Engineering, Case Western Reserve University, 44106, Cleveland, OH
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Abstract: | The dynamic behavior of a batch culture of yeast with a rate-limiting nutrient was analyzed by examining the cell number density, cell size distribution, and concentration of a rate-limiting nutrient. The particular strain of S. cerevisiae studied grows only when the medium contains L-tryptophan. The cell number, volume distribution, and external L-tryptophan concentration were measured at successive times in the development of the culture. A mathematical model was developed to simulate the experimental data and provide a framework for understanding the dynamics of the cell growth and division in terms of cellular events. A nonlinear optimization procedure was specially adapted to estimate model parameters. |
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